Endocrine Abstracts

Objective: Polycystic ovary syndrome (PCOS) is characterized by biochemical and clinical androgen excess and disturbed ovarian function and is associated with disorders of glucose and lipid metabolism. Isoflavones are phytoestrogens exerting endocrine effects on human hormone and metabolic signaling and may influence symptom penetrance in PCOS. We investigated whether women with PCOS and healthy controls have alterations in their capacity to metabolize hormonally active dietar...

17α-hydroxyprogesterone (17OHP) is currently used as a diagnostic parameter in children and young adults when a milder form of congenital adrenal hyperplasia (CAH, late-onset) is suspected. A basal serum level of 17OHP (2 ng/ml; 6.0 nmol/l, respectively) has been discussed as cut-off for suspected late-onset disease. We analysed 17OHP in a cohort of children and adolescents without CAH and in confirmed CAH patients to define reference ranges for these age...

Introduction: Testosterone production in male testicular cells is mainly stimulated by LH, secreted by the pituitary. Recent findings have shown significant clinical associations of vitamin D seasonal rhythms and androgens in men (Wehr et al. 2010, Nimptsch et al. 2012). We aimed to elucidate associations of vitamin D and androgen synthesis on a cellular level.Methods: Human primary testicular cells, isolated from testes of braindead donors, and a cell l...

Objective: Insulin-like growth factor 1 (IGF1) has a crucial role in growth and metabolism. A specifically designed autoantibody (aAb) assay against the IGF1 receptor (IGF1R-aAb) is able to detect IGF1R-aAb in serum. As the IGF1R has shown involvement in many functional pathologies (e.g. in the Laron syndrome), we aimed to investigate the role of IGF1R-aAb in a large population-based cohort of middle-aged volunteers and their potential effects on anthropometric, osteological a...

Roux-en-Y gastric bypass (RYGB) surgery results in rapid weight loss, reduced adiposity and improved overall metabolism. These health benefits cannot solely be attributed to the reduced caloric intake, but the exact mechanisms are still incompletely understood. Several studies in rodents and humans demonstrated alterations of the gut microbiota following RYGB, suggesting a crucial role of the host-microbial interactions for the beneficial effects of surgery. This study aimed t...